Symptoms Of Toxoplasmosis In Humans You Shouldn’t Ignore

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Common Symptoms Of Toxoplasmosis In Humans

One of the top three parasitic infections, toxoplasmosis symptoms are often mild in healthy individuals but can be severe in people with weakened immune system. It could manifest as flu, encephalitis or even schizophrenia. In pregnancy, it affects the fetus more than the mother. In babies and children, toxoplasmosis can result in birth defects, eye disorders, developmental issues, etc

When it comes to toxoplasmosis, you’ll discover that prevention really is better than cure. Toxoplasmosis is a parasitic infection caused by a single-celled parasite called Toxoplasma gondii. Normally, a healthy person’s immune system will prevent the disease from taking root. However, those with weakened immune systems and pregnant women are at a greater risk and need to be on the lookout to keep this deadly disease at bay. Severe cases of toxoplasmosis may even cause damage to the brain, eyes, and other vital organs.1

Before understanding the symptoms of toxoplasmosis, we need to know its causes. The Toxoplasma gondii parasite infects 30 to 80 percent of the global population and is interestingly related to the parasites that cause malaria and cryptosporidiosis, two other significant illnesses. Cat feces and raw meat are major carriers of the parasite. Humans mainly become infected with Toxoplasma gondii through contact with parasites transferred into the environment from infected cat feces, or by eating raw or undercooked infected meat.2

Toxoplasmosis can also be a result of accidentally ingesting unhygienically handled contaminated meat, drinking water contaminated with the parasite, or pregnant mother-to-child transmission. If you have a cat, you need to be extra careful. You may accidentally swallow the parasite shed in cat feces while cleaning the litter box or touching or ingesting anything that has come into contact with the feces. If your cat plays and defecates in your garden, make sure to wear gloves or wash your hands after gardening as the soil may get contaminated. Sandboxes for kids, whether at home or in parks, should be covered when not in use to prevent contamination with cat feces.3

Toxoplasmosis symptoms in humans are often mild and barely noticeable in the initial stages of the infection. But as the infection progresses, there will be some marked toxoplasmosis symptoms. However, they might differ in normal individuals, pregnant women, babies and those with compromised immunity such as AIDS patients. Here are the main toxoplasmosis symptoms in normal human beings.

1. Flu

Fever, sore throat, tender lymph nodes, muscular pain and other such flu-like symptoms are some early signs of toxoplasmosis. This is why it can be easy to dismiss toxoplasmosis as just another flu onset. The flu might last for a couple of weeks to some months.4

2. Encephalitis

Encephalitis is an inflammation of the brain that can cause headaches and confusion. Patients may also experience disorientation, drowsiness, hemiparesis (weakness in one side of the body), reflex changes, and convulsions. They may even become comatose in severe cases.5

3. Behavioral Alterations

Toxoplasmosis symptoms in human behavior have been extensively studied. Some studies even claim a link between the Toxoplasma gondii parasite and schizophrenia. The parasite may have effects on dopamine and testosterone levels in the body that directly affect our mood. Reduced psychomotor performance is another one of the main symptoms of toxoplasmosis.6

Research has also shown a gradual change in the personality traits of infected men and women as opposed to uninfected individuals. Could there really be toxoplasmosis brain symptoms that affect one’s personality? According to a study, infected men were shown to be more self-serving, suspicious, jealous and dogmatic, whereas infected women were noted to have more warmth and superego strength.7

Toxoplasmosis Symptoms In Pregnancy

If a pregnant woman becomes infected during or just before pregnancy, the symptoms will affect the fetus more than the woman in most cases. Interestingly, the mother rarely shows symptoms of infection, though she does have a temporary parasitemia. As far as the fetus is concerned, focal lesions develop in the placenta and the fetus may become infected. Initially, there is generalized infection in the fetus. Eventually, infection is cleared from the visceral tissues and may end up in the central nervous system.8

The effect will be more severe if the infection occurs during the earlier stages of pregnancy. It can cause miscarriage, stillbirth, premature birth or an infant with signs of the toxoplasmosis infection such as an abnormally large or small head. However, if a woman has been infected with toxoplasmosis prior to pregnancy, the unborn child will be protected because the mother has the advantage of having developed immunity.9

Toxoplasmosis Symptoms In Babies And Children

Congenital toxoplasmosis can lead to the development of deadly diseases in babies and children. When there is the mother-to-fetus transmission of toxoplasmosis, it can result in a number of birth defects and anomalies in the newborn. These might include hydrocephalus (water on the brain), abnormally small head, intracranial calcifications, blindness and other eye issues, epilepsy, psychomotor and mental retardation, petechiae, and anemia. Symptoms of congenital toxoplasmosis can even crop up years after birth and families of such children are advised to make the child undergo regular clinical and ophthalmologic examinations in case of toxoplasmosis eye symptoms or those who have ocular toxoplasmosis.10

In most cases, these issues are treatable with regular medical care.

Symptoms In People With Weakened Immune System

Unfortunately, toxoplasmosis ranks high on the list of diseases which lead to death in patients with AIDS. About 10 percent of AIDS patients in the USA and up to 30 percent in Europe are estimated to die from toxoplasmosis.
11

Symptoms of toxoplasmosis in adults with compromised immunity may be severe. These include those suffering from HIV AIDS, cancer patients receiving chemotherapy, recent organ transplant patients. If such people were never infected with Toxoplasma gondii previously, they are more likely to develop a severe primary infection on exposure. However, those who were infected with toxoplasmosis before their immunity was weakened by such conditions can have a relapse. This is because the Toxoplasma gondii parasite remains in the body in an inactive state long after the infection subsides and may reactivate to wreak havoc again. A relapse of toxoplasmosis may have symptoms like fever, confusion, headache, seizures, nausea, and poor coordination.12

References   [ + ]

1, 3, 12.What is toxoplasmosis? CDC.
2.Toxoplasmosis. WEHI.
4, 5, 8, 11.Hill, D., and J. P. Dubey. “Toxoplasma gondii: transmission, diagnosis and prevention.” Clinical microbiology and infection 8, no. 10 (2002): 634-640.
6.Flegr, Jaroslav. “Effects of Toxoplasma on human behavior.” Schizophrenia bulletin 33, no. 3 (2007): 757-760.
7.FLEGR, J., S. ZITKOVÁ, P. KODYM, and D. FRYNTA. “Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii.” Parasitology 113 (1996): 49-54.
9, 10.Chaudhry, Shahnaz Akhtar, Nanette Gad, and Gideon Koren. “Toxoplasmosis and pregnancy.” Canadian Family Physician60, no. 4 (2014): 334-336.

Disclaimer: The content is purely informative and educational in nature and should not be construed as medical advice. Please use the content only in consultation with an appropriate certified medical or healthcare professional.

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