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What Is Yohimbine? Learn About Its Uses And Side Effects

Yohimbine is found in the bark of the yohimbe tree in Western Africa. It’s been used as a natural erectile dysfunction remedy for thousands of years. Researchers think it works by alpha-2 adrenoceptors, which inhibit erections. There are also mixed findings on yohimbine’s benefits for weight loss and exercise. Before seeking out yohimbine, know that the potential side effects include irritability, headache, and nausea. Many brands also don’t have accurate labeling, so be careful.

In the midst of fish oil and coenzyme Q10, yohimbine sounds like something from a faraway land. If you’re in America, that might very well be the case! Yohimbine is found in Africa and has been used as a herbal medicine for thousands of years. It’s also been gaining popularity in the Western world – but what does it do?

After learning about the benefits, you may be tempted to scope out supplements. But like all holistic medicines, there are pros and cons to consider. Here’s what you need to know about yohimbine.

What Is Yohimbine?

Yohimbine, pronounced “yo-him-been,” is a compound found in the bark of the yohimbe tree.1 It’s an evergreen plant that’s native to Western Africa. In supplement form, yohimbine can be taken as extracts, tablets, capsules, or tea.2

Health Uses Of Yohimbine

1. Improves Erectile Dysfunction

If yohimbine is known for one thing, it’s the ability to treat erectile dysfunction (ED). The condition affects 30 million men and the risk increases with age.3 And as awareness about natural supplements increases, more and more people are seeking to use it.

Yohimbine’s claim to fame makes sense. In some parts of Africa, it’s used as an aphrodisiac.4 Natural supplements for sexual dysfunction often include yohimbine, along with herbs like ginseng, maca, and horny goat weed.

Researchers think yohimbine works by blocking alpha-2 adrenoceptors. These receptors inhibit ED-related pathways in the central nervous system, making an erection out of the question! But by standing in the way, yohimbine is thought to enhance the central sexual impulse.

It’s also thought to release nitric oxide, a compound that dilates blood vessels and increases blood flow.5

2. May Induce Weight Loss

The findings on yohimbine and weight loss are mixed. As it blocks alpha-2 adrenoceptors, the effect speeds up cell activity. This is thought to extend the process of fat breakdown called lipolysis. In a way, it works similarly to the thermogenic effects of caffeine.6

Back in 1991, a study looked at how yohimbine affected 20 obese females. They ate 1,000 calories every day for 3 weeks, but only some received the supplement. The yohimbine group lost 7.8 pounds while the control group only lost 4.9 pounds, on average.7

However, other studies haven’t found a solid connection to lipolysis.8 More research is certainly needed before pegging yohimbine as a weight loss supplement.

3. Enhances Exercise

The supposed link to lipolysis has also attracted bodybuilders. According to a 2002 study in Medical Hypotheses, yohimbine is thought to increase levels during and after exercise. It may even improve the ratio of inhaled oxygen and exhaled carbon dioxide.9 But again, until more research is done, bodybuilders should be cautious.

Potential Dangers Of Yohimbine

Yohimbine has been used for thousands of years and it comes from a tree. So what’s the big fuss?

1. Harmful Side Effects

Based on human data, yohimbine is known to have adverse side effects. Common complaints include irritability, headache, nausea, anxiety, and increased urge to pee. In some cases, gastric complaints, high blood pressure, and allergic reactions were also reported.10

2. Inaccurate Labeling

Unfortunately, labels aren’t always truthful. They also aren’t regulated by the Food & Drug Administration! In fact, a 2016 study examined the content of 49 yohimbine supplements. Only 4.1 percent were accurate, and actual levels ranged from 23 to 147% of the label.11 Accidentally overdosing will be far too easy.

Are you interested in yohimbine? Buy from a reputable company and follow the directions. Otherwise, given the discrepancies in research, it may be safer to avoid the supplement.

References   [ + ]

1. Yohimbine. LiverTox, United States National Library of Medicine.
2, 4. Yohimbe. National Center for Complementary and Integrative Health.
3. Nunes KP, Labazi H, Webb RC. New insights into hypertension-associated erectile dysfunction. Current Opinion in Nephrology and Hypertension. 2012;21(2):163–170.
5. Corazza, Ornella, Giovanni Martinotti, Rita Santacroce, Eleonora Chillemi, Massimo Di Giannantonio, Fabrizio Schifano, and Selim Cellek. “Sexual enhancement products for sale online: Raising awareness of the psychoactive effects of yohimbine, maca, horny goat weed, and Ginkgo biloba.” BioMed research international 2014 (2014).
6. Alkhatib, Ahmad, Marcos Seijo, Eneko Larumbe, and Fernando Naclerio. “Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise.” Journal of the International Society of Sports Nutrition 12, no. 1 (2015): 44.
7. Kucio, C., K. Jonderko, and D. Piskorska. “Does yohimbine act as a slimming drug?.” Israel journal of medical sciences 27, no. 10 (1991): 550-556.
8. Berlin, I., A. Stalla-Bourdillon, Y. Thuillier, G. Turpin, and A. J. Puech. “Lack of efficacy of yohimbine in the treatment of obesity.” Journal de pharmacologie 17, no. 3 (1986): 343-347.
9. McCarty, Mark F. “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis.” Medical hypotheses 58, no. 6 (2002): 491-495.
10. EFSA ANS Panel. “Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille).” EFSA Journal 11, no. 7 (2013): 1-46.
11. Cohen, Pieter A., Yan‐Hong Wang, Gregory Maller, Renan DeSouza, and Ikhlas A. Khan. “Pharmaceutical quantities of yohimbine found in dietary supplements in the USA.” Drug testing and analysis 8, no. 3-4 (2016): 357-369.

Disclaimer: The content is purely informative and educational in nature and should not be construed as medical advice. Please use the content only in consultation with an appropriate certified medical or healthcare professional.