Parkinson's sets in as neurotoxins (rotenone, synuclein, etc.) upset cellular pathways that support motion. This leads to neural damage and loss, motor defects, low dopamine levels, and cellular death in brain cells that release dopamine. Use TGY (a Chinese decoction) to lower neurotoxicity, stabilize dopamine levels, and preserve neural and motor function. Its antioxidants flavonoids and iridoids help prevent cell death.
Neurodegenerative disorders are extremely prevalent in aging populations because the natural course of aging involves cognitive decline.
Parkinson’s disease (PD) is among the most common age-dependent brain disorders. It is classified as a starting tremor in hands that exacerbates to compromised motor functions. The nervous system is impacted in the area that controls motion, causing delayed or slower motion as well as stiffness. Motion extends from the limbs to the facial region, with masked expressions and slurred speech.
What Causes Parkinson’s?
A variety of genetic and environmental influences have been examined in the etiology of PD. Neurotoxins in the environment can drive the onset of Parkinson’s disease by interfering with cellular pathways that support proper motion. Genome-wide studies further revealed familial genetic factors that contain genes proven to be causal of this neurodegenerative disorder. With age comes susceptibility to interfering medications, improper medication use, and compromised immunity, necessitating holistic treatment for cognitive impairment.
Can It Be Cured?
Traditional Chinese medicine is an explored answer to this call for safe and natural remedies in Parkinson’s disease development. One in particular, Tianma Gouteng Yin (TGY), is a Chinese decoction frequently implemented for the treatment of tremors and paralysis1. (Chinese decoction is the process of boiling crude herbs and extracting water to concentrate a pure substance in the herb.)
Neurotoxins Versus TGY
Flies exposed to the neurotoxin rotenone were administered doses of TGY to observe effects. TGY not only promoted higher survival rates in the flies but it also improved motor functionality and stamina. Rotenone is capable of inducing cellular death in dopaminergic brain cells. TGY significantly prevented cellular death despite rotenone mechanisms. These results were mirrored in a rat model as well, translating the findings into mammalian species.
Synuclein is another player involved in Parkinson’s disease, whose protein overproduction inflicts neural damage and motor defects. In addition, this neurotoxin acts to reduce dopamine levels in the brain and promote neuron loss. In flies with overexposed synuclein, treatment of TGY showed significant improvement in motor function despite the presence of a neural inhibitor. TGY preserved neuron content in the brain and stabilized dopamine levels, indicating preserved neural capabilities. By reducing neurotoxicity in the brain, TGY was able to reverse and further prevent the damage of synuclein on physical function of the flies.
This study supported the use of Tianma Gouteng Yin for Parkinson’s disease treatment by illustrating its ability to reverse and prevent the actions of harmful neurotoxins in the brain. Flavonoids and iridoids in the decocted TGY are known as anti-inflammatory and antioxidant agents that can also prevent cellular death. These components are likely responsible for the observed benefits of TGY in Parkinson’s disease treatment.
References [ + ]
|1.||↑||Liu, Liang-Feng, Ju-Xian Song, Jia-Hong Lu, Ying-Yu Huang, Yu Zeng, Lei-Lei Chen, Siva Sundara Kumar Durairajan, Quan-Bin Han, and Min Li. “Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease.” Scientific reports 5 (2015).|